Ultraviolet (UV) radiation is the primary cause of skin photoaging, leading to degradation of extracellular matrix components, hyperpigmentation, and loss of skin elasticity. Polyphenols have attracted significant attention for their antioxidant, anti-inflammatory, and anti-aging properties. The effects of the pomegranate extract on skin health parameters were studied in human fibroblast Hs68 cells under normal and UV-induced photoaging conditions.

Pomegranate extract standardized with the potent antioxidant – punicalagins significantly modulated collagen and hyaluronic acid metabolism under normal conditions. In UV-exposed cells, preventive and regenerative treatments improved hyaluronic acid metabolism and reduced reactive oxygen species (ROS) levels, while only preventive treatment influenced collagen metabolism. Additionally, pomegranate extract standardized with punicalagins demonstrated potent tyrosinase inhibition. These findings highlight the potential of pomegranate extract as a multifunctional agent for skin health and anti photoaging applications.

Other studies suggest that biophenol-rich pomegranate extract may improve cardiovascular risk profiles, lower stress hormone levels, and enhance perceived health-related quality of life. Notably, the observed reduction in salivary cortisol could be especially beneficial for individuals experiencing chronic stress.

References:

1. https://pubmed.ncbi.nlm.nih.gov/36358496/
2. https://pubmed.ncbi.nlm.nih.gov/30925733/
3. https://pubmed.ncbi.nlm.nih.gov/36076824/
4. https://www.mdpi.com/1999-4923/16/4/458